摘要
变应性鼻炎是常见的变态反应性疾病,近年来发病率呈上升趋势。其发病与外界环境关系密切,表观遗传学修饰在本病的发生中扮演重要角色。本文就近年来表观遗传学在变应性鼻炎研究的DNA甲基化、组蛋白修饰、miRNAs表达等进行综述。
Allergic rhinitis(AR)is one kind of common allergic diseases.The incidence of AR has been on the rise in recent years.The onset of AR has been closely related with external environment and epigenetic modification plays an important role in the pathogenesis of AR.The progress on epigenetics of AR,such as DNA methylation,histone modification,and miRNAs expression are reviewed in this article.
作者
朱栋
何翔
李国平
ZHU Dong;HE Xiang;LI Guo-ping(State Key Laboratory of Quality Research in Chinese Medicine,Macao University of Science and Technology,Macao,999078,China;Chengdu Institute of Respiratory Health,Branch of National Clinical Research Center for Respiratory Disease,The Third People's Hospital of Chengdu,Chongqi Medical university,Chengdu 610031,China)
出处
《中华临床免疫和变态反应杂志》
CAS
2021年第1期64-68,共5页
Chinese Journal of Allergy & Clinical Immunology
基金
国家自然科学基金(8197010598、82000029)
四川省应用基础研究基金(2018JY0380)
四川省卫生健康委员会科研基金(19ZD002)。
