EZH2在消化系统肿瘤中的研究进展

Progress in research of EZH2 in digestive system tumors

果蝇Zeste基因增强子人类同源物2(enhancer of Zeste homolog 2,EZH2)是多梳蛋白家族(polycomb group,PcG)中关键成员之一,也是多梳抑制性复合物2(polycomb repressive complex 2,PRC2)复合物中具有催化活性的亚单位,具有组蛋白甲基化转移酶活性,在表观遗传修饰过程中扮演重要角色.大量研究表明,它与多种消化系统肿瘤的发生发展、转归预后密切相关,在肿瘤组织中呈高表达,例如食管癌、胃癌、肝癌、结直肠癌、胰腺癌、胆囊癌等.本文总结了EZH2的生物学特性及其在消化系统肿瘤中的研究进展,并对EZH2的靶向治疗方面提出了展望.

EZH2 is a key member of the PcG protein family and a subunit of catalytic activity in the PRC2 complex.It has histone methylation transferase activity and plays an important role in epigenetic modification.A large number of studies have shown that it is closely related to the occurrence,development,and prognosis of various digestive system tumors and is highly expressed in tumor tissues,such as gastric cancer,liver cancer,colorectal cancer,pancreatic cancer,and gallbladder cancer.In this paper,we review the biological characteristics of EZH2d,its role in digestive system tumors,and the prospect of targeted therapy for EZH2.