MCs介导的COX2-PGE2-Eps信号通路在IBS内脏高敏感性中的机制研究

Mechanism of mast cell-mediated COX2-PGE2-Eps signaling pathway in visceral hypersensitivity in irritable bowel syndrome

肠易激综合征(irritable bowel syndrome,IBS)是功能性胃肠病的一种,其病理生理机制复杂,涉及遗传因素、心理社会因素、黏膜低度炎症、肠道屏障改变、肠道菌群紊乱、神经免疫异常及内脏高敏感性等多种机制.近年来,内脏高敏感性在IBS中的作用机制成为研究热点.肥大细胞(mast cells,MCs)是分布在中枢系统及消化系统的一种免疫细胞,其活化介导的COX2-PGE2-Eps信号通路从外周致敏及中枢敏化多方面协同作用参与了IBS内脏高敏感性的发生,为进一步明确IBS的病理机制提供了新的思路.

Irritable bowel syndrome(IBS)is a functional gastrointestinal disorder(FGID)whose pathophysiological mechanism is complex,involving genetic factors,psychosocial factors,low-grade mucosal inflammation,changes in the intestinal barrier,bacterial flora disorder,neuroimmune abnormalities,and high visceral sensitivity.In recent years,the mechanism of visceral hypersensitivity in IBS has become a hot research topic.Mast cells(MCs)are a group of immune cells that are distributed in the central nervous system and digestive system.The COX2-PGE2-Eps signaling pathway plays a major role in the visceral hypersensitivity in IBS,from peripheral sensitization to central sensitization,which provides a new idea for further clarifying the pathological mechanism of IBS.