肿瘤干细胞在结直肠癌耐药及转移过程中作用的 研究进展

Progress in understanding the role of tumor stem cells in drug resistance and metastasis in colorectal cancer

结直肠癌是全世界癌症相关死亡的主要原因之一,绝大多数结直肠癌患者死于外科手术后的复发和转移。越来越多的证据揭示了肿瘤干细胞(CSC)的存在及其在增强治疗抵抗和转移中的作用。CSC是肿瘤细胞中的一小部分,它能引发肿瘤的形成并使肿瘤产生异质性。此外,CSC对各种细胞毒因子有抵抗力并因此使结直肠癌术后患者产生耐药及转移。本文就近年来有关结直肠癌干细胞在肿瘤的耐药性及肿瘤转移方面的研究进展进行综述,以期为结直肠癌的治疗策略的选择提供参考。

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide.The vast majority of colorectal cancer patients die of recurrence and metastasis after surgery.More and more evidence has revealed the existence of cancer stem cells(CSC)and its role in cancer resistance and metastasis.Tumor stem cells are a small fraction of tumor cells that can trigger tumor formation and make the tumor heterogeneous.In addition,tumor stem cells are resistant to a variety of cytotoxic factors and thus result in drug resistance and metastasis in patients with colorectal cancer after surgery.