摘要
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)所致冠状病毒疾病2019(COVID-19)已构成国际关注的突发公共卫生事件。COVID-19传染性强,可导致患者出现严重呼吸道感染和多器官系统功能损害。COVID-19发病机制尚不明确,我们推测SARS-CoV-2直接致宿主靶细胞损伤及机体免疫炎症反应紊乱可能是COVID-19的主要致病机制。本文基于相关研究领域的进展,对COVID-19发病机制中的若干热点问题进行分析和讨论,并提出思考。
Coronavirus disease 2019(COVID-19)induced by severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)has constituted a public health emergency of international concern.COVID-19 is highly contagious and can lead to severe respiratory infections and multiple organ system dysfunction.The pathogenesis of COVID-19 remains unclear,and it is speculated that host cell injury directly caused by SARS-CoV-2 and immune inflammation disorder may be the main pathogenic mechanisms of COVID-19.Based on the achievements of related research,we summarize and interpret several hot issues in the pathogenesis of COVID-19,and put forward some viewpoints.
作者
刘军
Liu Jun(Department of Critical Care Medicine,Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou 215001,China)
出处
《中华临床医师杂志（电子版）》
CAS
2020年第10期753-758,共6页
Chinese Journal of Clinicians(Electronic Edition)
基金
江苏省第五期“333工程”科研项目(BRA2016070)
苏州市科技发展计划项目(SS201874)。
