肿瘤免疫治疗机制及乳腺癌免疫治疗进展

Mechanism of immunotherapy and progress in immunotherapy of breast cancer

肿瘤的发生、发展与肿瘤及微环境之间所形成的肿瘤生态系统密不可分,基础研究成果的临床转化促使乳腺肿瘤医师能够更系统、更全面的去探索和制定有效的治疗方案。基于此,免疫治疗的日渐兴起正在改变乳腺癌系统治疗的格局,免疫治疗联合传统治疗方案,可进一步改善乳腺癌患者的预后。发现新的免疫治疗靶点、寻找更优的预测抗肿瘤免疫治疗效果的生物标志物和目标人群,是未来提升临床乳腺癌抗肿瘤免疫治疗效果的重要探索方向。

Tumorigenesis and tumor progression are inseparable from the tumor ecosystem consisting of the tumor itself and its microenvironment.The clinical translation from bench to bedside can help breast oncologists develop more comprehensive and effective treatment strategies for breast cancer.The rise of immunotherapy is changing the pattern of systemic treatment of breast cancer.Combination of immunotherapy with traditional treatment can further improve the prognosis of breast cancer patients.In the future,discovering new targets and more accurate predictive biomarkers for anti-tumor immunotherapy are of importance to improve the clinical effect of immunotherapy for breast cancer patients.