胶质瘤与恶性脑膜瘤患者肿瘤组织ABCG2、IGFBP-2表达及预后的关系分析

Relationship between ABCG2 and IGFBP-2 expression and prognosis in glioma and malignant meningioma patients

目的探讨胶质瘤与恶性脑膜瘤患者肿瘤组织三磷酸腺苷结合转运蛋白G超家族成员2(ABCG2)、胰岛素样生长因子结合蛋白-2(IGFBP-2)表达及预后的关系。方法选取资阳市第一人民医院确诊胶质瘤患者96例和恶性脑膜瘤患者38例,采用免疫组化法检测患者肿瘤组织中ABCG2、IGFBP-2阳性细胞的表达,计算其阳性细胞百分率并划分阳性等级,并对比两组ABCG2、IGFBP-2表达差异及与预后死亡和复发的关系。结果胶质瘤组肿瘤组织ABCG2、IGFBP-2总阳性率与恶性脑膜瘤组比较,差异有统计学意义(P<0.05)。胶质瘤组随访中复发率和病死率与恶性脑膜瘤组比较,差异无统计学意义(P>0.05)。生存分析曲线结果显示,ABCG2、IGFBP-2高表达组出现不良事件(死亡、神经功能中度缺损)时间提前于低表达组,差异有统计学意义(P<0.05)。结论随着胶质瘤、恶性脑膜瘤患者肿瘤组织ABCG2、IGFBP-2阳性细胞百分率等级的升高,其预后的复发率与病死率也逐级升高。

Objective To investigate the relationship between the expression and prognosis of adenosine triphosphate binding cassette transporter protein superfamily member G2(ABCG2)and insulin-like growth factor binding protein 2(IGFBP-2)in glioma and malignant meningioma patients.Methods A total of 96 patients with confirmed glioma and 38 patients with malignant meningioma were included from the First People′s Hospital of Ziyang.The expression of ABCG2 and IGFBP-2 in tumor tissues were determined by immunohistochemistry,and the ABCG2 and IGFBP-2 positive cells were calculated and classified.The differences in expression between the two groups were compared,and the association with death and recurrence prognosis were analyzed.Results The total positive rates of ABCG2 and IGFBP-2 in glioma group were significantly different from those in malignant meningioma group(P<0.05).There was no significant difference in the recurrence rate and mortality between the glioma group and the malignant meningioma group during follow-up(P>0.05).The results of survival analysis curve showed that the time of adverse events(death and moderate neurological impairment)in ABCG2 and IGFBP-2 high expression group was earlier than that in the low expression group(P<0.05).Conclusion With the increase of the percentage of ABCG2 and IGFBP-2 positive cells in glioma and malignant meningioma,the recurrence rate and mortality rate of prognosis are also increased step by step.