通脉滴丸联合西洛他唑治疗Ⅰ、Ⅱ期下肢动脉硬化闭塞症的临床疗效

Clinical Efficacy of Tongmai Dripping Pills Combined with Cilostazol on StageⅠ/ⅡArteriosclerosis Obliterans of Lower Extremity

目的:观察通滴脉丸联合西洛他唑治疗Ⅰ、Ⅱ期下肢动脉硬化闭塞症的临床疗效。方法:92例下肢动脉硬化闭塞症患者随机分为对照组(46例)和观察组(46例),分别给予西洛他唑、通脉滴丸联合西洛他唑治疗,疗程均为30 d。观察两组患者治疗前后踝肱指数(ABI),卢瑟福血栓闭塞性脉管炎分级量表(Rutherford分级),胫后动脉及足背动脉血流动力学指标(血管内径、收缩期血流速度峰值)。比较两组患者的临床疗效和不良反应。结果:观察组治疗总有效率91.1%,高于对照组的81.4%(P<0.05)。治疗后,观察组ABI增加、Rutherford分级降低较对照组更明显(P<0.05)。治疗后,观察组胫后动脉及足背动脉血流动力学指标改善均较对照组更明显(P<0.05)。两组患者不良反应发生率差异无统计学意义(P>0.05)。结论:通脉滴丸联合西洛他唑可有效改善Ⅰ、Ⅱ期下肢动脉硬化闭塞症患者的临床症状,不良反应发生率低。

Objective:To observe the clinical effect of Tongmai dripping pills combined with cilostazol onⅠ/Ⅱstage arteriosclerosis obliterans of lower extremity.Methods:92 cases arteriosclerosis obliterans of lower extremity were randomly divided into the control group(46 cases)and the observation group(46 cases),and cilostazol,Tongmai dripping pills combined with cilostazol were given for 30 days,respectively.The ankle brachial index(ABI),Rutherford thromboangiitis obliterans scale(Rutherford scale)and hemodynamic indicators of posterior tibial artery and dorsalis of foot(vessel diameter,peak systolic blood velocity)were observed before and after the treatment in both groups.The clinical efficacy and adverse reactions of the two groups were compared.Results:The total effective rate was 91.1%in the observation group,which was higher than that 81.4%in the control group(P<0.05).Compared with the control group after treatment,the ABI increasement,Rutherford grading decrement in the observation group were more obviously(P<0.05).Compared with the control group after treatment,the hemodynamic indicators of arterial and dorsal foot arteries in the observation group were improved more obviously(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion:Tongmai dripping pills combined with cilostazol can effectively improve the clinical symptoms in patients withⅠ/Ⅱstage arteriosclerosis obliterans of lower extremity,and the incidence of adverse reactions is low.