脓毒症相关性脑病早期预警因素研究

Study on Early Warning Factors of Sepsis-associated Encephalopathy

目的探讨分析脓毒症相关性脑病(SAE)发生的早期预警因素,及时进行治疗干预,改善预后。方法回顾性分析2018年12月至2019年12月郑州大学第二附属医院ICU收治的136例脓毒症患者的临床资料,按是否发生SAE将其分为SAE组(n=51)与非SAE组(n=85),对两组患者的一般资料及临床指标等相关因素进行比较分析,同时对有统计学差异的预警因素进行logistic回归分析。结果两组患者年龄、性别、PaCO_(2)差异无统计学意义(P>0.05)。血乳酸、PaO_(2)、PLT、D-二聚体、APACHEⅡ评分及白蛋白的差异比较有统计学意义(P<0.05)。Logistic回归分析提示D-二聚体、血乳酸、APACHEⅡ评分是SAE发生的早期预警因素(P<0.05)。结论血乳酸、D-二聚体、APACHEⅡ评分与SAE的发生密切相关,针对预警因素采取相应的预防措施,可明显降低SAE的发生率。

Objective To analyze the early warning factors of sepsis-related encephalopathy(SAE),and to improve the prognosis by timely intervention.Methods The clinical data of 136 patients with sepsis admitted to ICU of the Second Affiliated Hospital of Zhengzhou University from December 2018 to December 2019 were analyzed retrospectively.SAE patients were divided into SAE group(N=51)and non-SAE group(N=85)according to their occurrence,the general data and clinical indexes of the two groups were compared and analyzed,and the early warning factors with statistical difference were analyzed by logistic regression.Results There were no significant differences in age,sex and PaCO2 between the two groups(P>0.05).Blood lactate,PaO2,PLT,D-dimer,APACHE II score and albumin were significantly different(P<0.05).Logistic Regression analysis indicated that D-dimer,blood lactic acid and APACHE II score were early warning factors for SAE(P<0.05).Conclusion Blood lactic acid,D-dimer and APACHE II score are closely related to SAE,preventive measures should be taken according to early warning factors,which can reduce the incidence of SAE.