莫沙必利、多潘立酮治疗功能性消化不良的效果对比研究

A Comparative Study of Mosapride and Domperidone in the Treatment of Functional Dyspepsia

目的研究莫沙必利、多潘立酮治疗功能性消化不良的临床效果。方法将76例功能性消化不良患者根据治疗方法分组,每组38例。Mos组给予莫沙必利治疗,Dom组给予多潘立酮治疗。比较两组治疗效果。结果治疗7 d,Dom组治疗总有效率高于Mos组(P<0.05);治疗14、28 d,两组治疗总有效率组间无明显差异(P>0.05)。治疗后1个月、3个月,两组复发率差异不显著(P>0.05);治疗后6个月,Dom组复发率高于Mos组,组间差异明显(P<0.05)。结论莫沙必利治疗功能性消化不良,显效速度快,疾病复发风险低。

Objective To study the clinical effects of mosapride and domperidone in the treatment of functional dyspepsia. Methods Seventy-six patients with functional dyspepsia were divided into groups according to treatment methods, with 38 cases in each group. The Mos group was treated with mosapride, and the Dom group was treated with domperidone. Compare the treatment effects of the two groups. Results After 7 days of treatment, the total effective rate of the Dom group was higher than that of the Mos group(P<0.05);after the 14 d and 28 d, there was no significant difference in the total effective rate between the two groups(P>0.05). One month and 3 months after treatment, there was no significant difference in the recurrence rate between the two groups(P>0.05);6 months after treatment, the recurrence rate of the Dom group was higher than that of the Mos group, and the difference between the groups was significant(P<0.05). Conclusion Mosapride is effective in treating functional dyspepsia with a fast speed and low risk of disease recurrence.