摘要
目的探讨IGF-1在胃癌患者血清中的表达及与肿瘤标志物CEA、CA125、CA199和CA724的相关性。方法电化学发光法检测血清肿瘤标志物CEA、CA125、CA199、CA724的水平;采用酶联免疫分析法检测血清中IGF-1的水平;Pearson分析IGF-1与CEA、CA125、CA199和CA724的相关性。结果胃癌患者血清中CEA、CA125、CA199、CA724及IGF-1的水平均高于良性胃部疾病患者和健康对照组。胃癌Ⅲ期和Ⅳ期患者血清中CEA、CA125、CA199、CA724及IGF-1的水平明显高于Ⅰ期和Ⅱ期患者血清中的水平。胃癌患者血清中IGF-1的表达水平与CEA、CA125、CA199、CA724的表达水平呈正相关。结论同时检测血清中IGF-1及CEA、CA125、CA199、CA724的表达水平,可为胃癌的早期诊断提供可靠的理论依据,对胃癌预后判断也有一定的指导意义。
Objective To investigate the expression of IGF-1 in gastric cancer patients serum and the correlation with tumor markers CEA,CA125,CA199 and CA724.Methods Using electrochemical luminescence to detect the levels of CEA,CA125,CA199,CA724 in the serum tumor markers;Using enzyme-linked immunoassay to measure the levels of serum IGF-1;the relevance analysis of IGF 1 and CEA,CA125,CA199,CA724 by Pearson.Results The levels of CEA,CA125,CA199,CA724 and IGF-1 in the gastric cancer patients serum were higher than in benign gastric disease patients and healthy controls.InⅢstage andⅣstage gastric cancer patients serum,the levels of CEA,CA125,CA199,CA724 and IGF-1 were obviously higher than that of patients with stageⅠandⅡlevels in the serum.The expression level of IGF-1 and CEA,CA125,CA199,CA724 were positively correlated in gastric cancer patients serum.Conclusion The detection of the expression level of IGF-1 and CEA,CA125,CA199,CA724 in serum can provide reliable theoretical basis for the early diagnosis of gastric cancer,for gastric cancer prognosis judgment also provied certain guiding significance.
作者
王宁
付立业
隋承光
孟凡东
李妍
WANG Ning;FU Li-ye;SUI Cheng-guang(Department of Tumor Interventional Therapy and Comprehensive Treatment,The Sixth People’s Hospital Shenyang,Liaoning Shenyang 110006,China;The First Hospital Affiliated to China Medical University,Oncdogy Institution,Liaoning Shengyang 110001,China)
出处
《中国实验诊断学》
2021年第2期194-197,共4页
Chinese Journal of Laboratory Diagnosis
