女性甲状腺乳头状癌患者274例临床病理特征分析

Analysis of clinical pathological features of 274 cases of papillary thyroid carcinoma in women

目的:分析女性甲状腺乳头状癌(PTC)患者274例临床病理特征。方法:选取2018年8月-2020年7月甲状腺全切手术或次全切手术且术后病理证实为PTC患者332例;其中女性患者274例,作为试验组;男性患者58例,作为对照组。分析不同性别PTC患者在年龄、肿瘤大小、肿瘤数目、淋巴结转移、周围组织侵犯及合并其他良性甲状腺疾病等临床因素的差异。结果:274例女性患者中,年龄<55岁236例;微小灶94例,多灶129例;伴中央区淋巴结转移176例,伴侧颈区淋巴结转移35例,侵犯包膜186例,合并结节性甲状腺肿120例,合并慢性淋巴细胞性甲状腺炎(CLT)51例。女性PTC患者包膜侵犯发生率明显低于男性PTC患者,差异有统计学意义(P<0.05);说明女性患者较男性患者更不易发生包膜侵犯;女性PTC患者合并慢性淋巴细胞性甲状腺炎的比例明显高于男性PTC患者,差异有统计学意义(P<0.05)。结论:女性甲状腺乳头状癌患者发病年龄轻,微小灶、多灶常见,易发生颈部淋巴结转移及周围组织侵犯,易合并多种良性疾病。

Objective:To analyze the clinical pathological features of 274 women with papillary thyroid carcinoma(PTC).Methods:From August 2018 to July 2020,332 cases of patients who underwent total thyroidectomy or subtotal surgery and confirmed as PTC were enrolled.Among them,274 female patients were enrolled as experimental group.58 male patients were enrolled as control group.The differences in clinical factors such as age,tumor size,tumor number,lymph node metastasis,surrounding tissue invasion and other benign thyroid diseases in PTC patients of different genders were analyzed.Results:Among 274 female patients,236 cases were younger than 55 years old.There were 94 cases of small lesions and 129 cases of multiple lesions.There were 176 cases with central lymph node metastasis,35 cases with lateral cervical lymph node metastasis,186 cases encroached the envelope,120 cases with nodular goiter,51 cases with chronic lymphocytic thyroiditis(CLT).The incidence of encroaching the envelope in female PTC patients was significantly lower than that in male PTC patients,the difference was statistically significant(P<0.05).The proportion of chronic lymphocytic thyroiditis in female PTC patients was significantly higher than that of male PTC patients,the difference was statistically significant(P<0.05).Conclusion:Female patients with papillary thyroid carcinoma are young in age,with common micro focus and multiple foci,which are prone to cervical lymph node metastasis and surrounding tissue invasion and easy to merge with a variety of benign diseases.