咪达唑仑联合早期机械通气治疗呼吸衰竭的效果分析

Effects of midazolam combined with early mechanical ventilation on oxygenation indexes,pulmonary function indexes and serum inflammatory factors in respiratory failure

目的:探讨为呼吸衰竭患者使用咪达唑仑联合早期机械通气疗法进行治疗对其脑耗氧量、肺功能指标及血清炎症因子水平的影响。方法:选取2019年1月至2020年1月期间远安县人民医院收治的70例呼吸衰竭患者作为研究对象。随机将这些患者分为对照组和观察组。对两组患者均进行常规治疗和早期机械通气治疗。在此基础上,为观察组患者使用咪达唑仑进行治疗。然后观察两组患者的脑耗氧量、FVC、FEV_(1)、PEF、血清TNF-α的水平、血清Hs-CRP的水平及血清IL-6的水平。结果:治疗后,观察组患者的脑耗氧量、血清TNF-α的水平、血清Hs-CRP的水平及血清IL-6的水平均低于对照组患者,其FVC及FEV_(1)均大于对照组患者,其PEF高于对照组患者,P<0.05。结论:使用咪达唑仑联合早期机械通气疗法对呼吸衰竭患者进行治疗能降低其脑耗氧量,改善其肺功能,减轻其体内的炎症反应。

Objective:To investigate the effects of midazolam combined with early mechanical ventilation therapy on cerebral oxygen consumption,lung function indexes and serum inflammatory cytokines in patients with respiratory failure.METHODS:A total of 70 patients with respiratory failure admitted to Yuan'an People's Hospital from January 2019 to January 2020 were selected as the research subjects.These patients were randomly divided into control group and observation group.Both groups were treated with routine treatment and early mechanical ventilation.On this basis,patients in the observation group were treated with midazolam.The cerebral oxygen consumption,FVC,FEV_(1),PEF,serum levels of TNF-α,serum hs-CRP and serum levels of IL-6 in 2 groups were observed.RESULTS:After treatment,the cerebral oxygen consumption,serum TNF-α level,serum hs-CRP level and serum IL-6 level in observation group were lower than those in control group,the FVC and FEV_(1) were higher than those in control group,and the PEF was higher than those in control group,P<0.05.Conclusion:The use of midazolam combined with early mechanical ventilation in patients with respiratory failure can reduce cerebral oxygen consumption,improve lung function,and reduce inflammation in vivo.