蒽环类药物相关心血管疾病与自主神经调控展望

Anthracycline-Induced Cardiovascular Diseases and Autonomic Nervous Regulation

蒽环类药物是临床实践中广泛使用的有效抗肿瘤药物,然而蒽环类药物相关心脏毒性副作用很大程度上限制了其临床应用。心脏自主神经系统紊乱参与了多种心血管疾病的发生和发展,通过调控自主神经实现再平衡可用于治疗心血管疾病。研究表明,蒽环类药物的使用与心脏自主神经失平衡密切相关。现就蒽环类药物相关心血管疾病及自主神经调控防治蒽环类药物相关心脏毒性的潜在机制进行综述,为临床防治蒽环类药物相关心血管疾病提供新思路。

Anthracyclines are effective anti-cancer drugs extensively used in clinical practice.However,the side effects of anthracycline-related cardiotoxicity have strongly influenced its clinical use.The cardiac autonomic nervous system disorders are involved in the occurrence and development of various cardiovascular diseases,and the regulation of autonomic nerve rebalance can be used in the treatment of cardiovascular diseases.Studies have shown that the use of anthracyclines is closely related to cardiac autonomic nervous imbalance.This article reviews the anthracycline-induced cardiovascular diseases and potential mechanisms of autonomic nervous regulation in the prevention and treatment of anthracycline-related cardiotoxicity,providing new ideas for clinical prevention and treatment of anthracycline-related cardiovascular diseases.