烟酰胺N-甲基转移酶的研究进展

Research progress on nicotinamide N-methyltransferase

烟酰胺N-甲基转移酶(NNMT)是一种甲基化酶,在体内能使烟酰胺(NAM)甲基化,生成N1-甲基烟酰胺(MNAM)从体内排出。近来的研究表明NNMT除了能够清除NAM外,还可以通过消耗甲基供体及生成活性代谢产物参与脂肪及肝脏等组织的多种代谢途径调节。本文对近年来研究发现的NNMT在生理和病理状态下的作用以及治疗干预新途径进行综述。

The enzyme,nicotinamide N-methyltransferase(NNMT),methylates nicotinamide(NAM)to form N1-methylated NAM.Recent studies have shown that NNMT not only clears NAM but also participates in the regulation of various metabolic pathways,such as those in adipose and liver tissues,by consuming methyl donors and producing active metabolites.Herein,the roles of NNMT under physiological and pathological conditions and new therapeutic interventions are reviewed.