Wnt/β-catenin通路与消化道肿瘤发生发展的关系被引量：1

Wnt/β-catenin Pathway and the Development of Gastrointestinal Tumors

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摘要 Wnt/β-catenin信号通路是调节胚胎发育及细胞增殖的重要途径之一,其异常激活会影响细胞正常的生长、增殖及迁移,在消化道肿瘤的发生发展中扮演着重要角色。本文对Wnt/β-catenin信号通路在食管癌、胃癌、结直肠癌等发病机制中的影响进行综述,探讨Wnt/β-catenin信号通路与消化道肿瘤发生发展的关系,为消化道肿瘤的靶向治疗提供新的研究思路。 Wnt/β-catenin signaling pathway is one of the important ways to regulate embryonic development and cell proliferation.Its abnormal activation will affect the normal growth,proliferation and migration of cells,and it plays an important role in the occurrence and development of gastrointestinal tumors.This article briefly reviews the influence of Wnt/β-catenin signaling pathway in the pathogenesis of esophageal cancer,gastric cancer,colorectal cancer,etc.,to explore the relationship between Wnt/β-catenin signaling pathway and the occurrence and development of gastrointestinal tumors,and to provide a new research idea for targeted therapy of digestive tract tumors.

作者米优嘉原翔刘怡文闫锦阳耿聪聪孙蔚高社干 MI You-jia;YUAN Xiang;LIU Yi-wen;YAN Jin-yang;GENG Cong-cong;SUN-Wei;GAO She-gan(Henan Key Laboratory of Cancer Epigenetics,the First Affiliated Hospital,and College of Clinical Medicine,of Henan University of Science and Technology,Luoyang,China,471003)

机构地区河南科技大学临床医学院

出处《食管疾病》 2021年第1期26-28,33,共4页 Journal of Esophageal Diseases

关键词 WNT信号通路消化道肿瘤发病机制 Wnt signaling pathway gastrointestinal tumors pathogenesis

分类号 R735.2 [医药卫生—肿瘤]

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1王一曌,郭琳,刘乙蒙,任丽莉,刘超,肖建英.Rack1与β-catenin在胃癌组织中的表达与临床意义[J].中国生化药物杂志,2016,36(3):30-33. 被引量：11
2秦燕子,王晓丽,刘明俊,王乐乐,单利娜,李卓然,陶仪声.β-catenin在食管癌侵袭转移过程中的作用[J].临床与实验病理学杂志,2017,33(8):832-836. 被引量：9

二级参考文献15

1Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013 [ J ]. CA Cancer J Clin ,2013,63 ( 1 ) : 11-30.
2Namikawa T, Kobayashi M, Kitagawa H, et al. Early gastric cancer with widespread duodenal invasion within the mucosa [ J ]. Dig Endosc, 2010,22 ( 3 ) :223-227.
3Loyer EM, David CL, Dubrow RA, et al. Vascular involvement in pancreatic adenocarcinoma: reassessment by thin-section CT [ J ]. Ab- dora Imaging, 1996,21 (3) :202-206.
4Yoon HM,Ryu KW, Nam BH, et al. ls the new seventh AJCC/UICC staging system appropriate for patients with gastric cancer[J].J AM Coil Surg,2012,214( 1 ) :88-96.
5Shi S, Deng YZ, Zhao JS, et al. Rackl promotes non-small lung cancer tumorigenicity through activating Sonic hedgehog signaling pathway. J Biol Chem,2012,287 ( 11 ) :7845-7858.
6Bird R J, Baillie GS, Yarwood SJ. Interaction with receptor for activated C-kinase 1 ( RACK1 ) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C [ J ]. Biochem J, 2010,432( 1 ) :207-216.
7Yang WH, Lan HY, Huang CH, et al. Rackl activation mediates Twistl- induced cancer cell migration [ J ]. Not Cell Biol, 2012, 40 ( 5 ) : 1553-1560.
8Lee HE,Park DJ, Kim WH, et al. Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma:novel therapeutic agents and advances in understanding. Tumor Biol,2013.34 (4) : 1999-2002.
9Deng YZ,Yao F, Li JJ, et al. Rackl Suppresses Gastric Tumorigenesis by Stabilizing the beta-catenin Destruction Complex [ J ]. GASTROE- NTEROLOGY,2012,142(4) :812-839.
10Liu AN, Zhu ZH, Chang SJ, et al. Twist expression associated with epithel-mesenchymal transition in gastric cancer [ J ]. Mol Cell Biochem,2012,367(1-2) :195-203.