摘要
食管癌的发生发展是基因变异和环境因素共同作用的结果,表观遗传学变化常受环境等后天因素调控,是食管癌复发和转移的关键驱动因素之一。本文综述参与食管癌发生和演进的表观遗传学变化,包括DNA甲基化、组蛋白修饰与染色质重塑、miRNA、长链非编码RNA等,分析总结表观遗传学变异在食管癌转移中的关键作用,为食管癌治疗提供新的思路和策略。
The development and progression of esophageal cancer is the collaborative consequence of genetic aberrations and environmental factors.Epigenetic dysregulation is widely linked to acquired factors,such as environmental factors,and plays a crucial role in recurrence and metastasis of esophageal cancer.In this review,we summarizes epigenetic alterations associated with development and progression of esophageal cancer,including DNA methylation,histone modifications and chromatin remodeling,miRNA,and long non-coding RNA,to provide insights into the roles of epigenetic events implicating in metastasis of esophageal cancer and novel approaches and strategies for therapeutic modality of esophageal cancer.
作者
齐义军
朱亚飞
李恩民
QI Yi-Jun;ZHU Ya-Fei;LI En-Min(Henan Key Laboratory of Cancer Epigenetics,Cancer Hospital,The First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang China,471003;The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area,Medical College of Shantou University,Shantou China,515041)
出处
《食管疾病》
2021年第1期58-63,共6页
Journal of Esophageal Diseases
基金
国家自然科学基金(81872037)
河南重大科技专项(161100311200)
广东省普通高校青年创新人才类项目(2018KQNCX085)。
关键词
食管癌
表观遗传学
肿瘤转移
esophageal cancer
epigenetics
tumor metastasis
