CCR7蛋白在肝细胞癌中的表达及临床意义

Expression and clinical significance of CCR7 protein in hepatocellular carcinoma

目的分析CC趋化因子受体7(CCR7)蛋白在肝细胞癌中的表达及临床意义。方法选取2016年1月至2017年6月南阳市第一人民医院收治的52例肝细胞癌患者作为研究对象,对肝细胞癌组织及配对癌旁组织的CCR7表达水平进行测定,以及对CCR7表达与预后的关系及临床病理特征进行分析。结果①52例患者肝细胞癌组织中,CCR7阳性率高于配对癌旁组织(65.38%vs.26.92%)(P<0.05)。②CCR7表达与性别、年龄、肝功能分级、肝硬化及乙肝病史无关(P>0.05),而与甲胎蛋白(AFP)水平、包膜完整有关(P<0.05)。③CCR7高表达组中1年生存率及无复发率低于低表达组,差异无统计学意义(P>0.05)。CCR7高表达组3年生存率及无复发率低于低表达组,差异有统计学意义(P<0.05)。结论CCR7的表达在肝细胞癌组织中明显升高,与AFP水平、包膜完整密切相关,其对患者3年生存率及复发率具有重要的评估价值。

【Objective】To analyze the expression and clinical significance of CC chemokine receptor 7(CCR7)protein in hepatocellular carcinoma.【Methods】A total of 52 patients with hepatocellular carcinoma who were treated in our hospital from January 2016 to June 2017 were selected as the research objects.The expression levels of CCR7 in hepatocellular carcinoma tissues and matched adjacent tissues were measured,and the relationship between CCR7 expression and prognosis and clinicopathological characteristics were analyzed.【Results】In 52 patients with hepatocellular carcinoma,the positive rate of CCR7 was 65.38%,which was higher than 26.92% of matched adjacent tissues(P<0.05).The positive result of CCR7 expression had nothing to do with the patient's sex,age,and history of hepatitis B(P>0.05),and was related to the integrity of the envelope and the level of alphafetoprotein(AFT)(P<0.05).The difference in the 1-year survival rate and no-recurrence rate between CCR7 high expression group(76.47%,79.41%)and low expression group(88.89%,94.44%)was not significant(P>0.05);the 3-year survival rate and norecurrence rate in CCR7 high expression group(32.35%,41.18%)were significantly lower than those in low expression group(66.67%,72.22%)(P<0.05).【Conclusion】The expression of CCR7 is significantly increased in hepatocellular carcinoma tissue,which is closely related to the integrity of the capsule and AFP.It has important evaluation value for the 3-year survival rate and recurrence rate of patients.