颅内动脉瘤的药物治疗研究进展

Research progress of medical therapy for intracranial aneurysm

颅内动脉瘤是以颅内动脉局部瘤状突起为特征的脑血管疾病,其病因学涉及到多种环境和遗传因素。当前对于颅内动脉瘤的治疗方式有限,除外科干预外,尚无其他有效治疗方法。对于未达手术指征的微小动脉瘤及不能耐受手术的患者,目前尚缺乏有效的控制手段。近年来研究表明,药物减轻局部动脉瘤炎性反应过程,可能延缓颅内动脉瘤的扩张,减少动脉瘤破裂风险。阿司匹林、他汀类、二肽基肽酶-4抑制剂等药物可能作为颅内动脉瘤的潜在治疗药物。笔者对颅内动脉瘤的病理生理进行了回顾总结,系统分析了用于治疗颅内动脉瘤的药物相关研究。

Intracranial aneurysm(IA)is a cerebrovascular disease characterized by local arterial wall dilation.The etiology of IA involves environmental and genetic factors.Currently,treatment methods for intracranial aneurysms are limited,and there are no other effective treatment methods except surgical intervention.At present,there is no effective control method for patients with small aneurysms while not meeting surgical indications and patients intolerant to surgery.In recent years,studies have found that medical therapy can reduce the inflammatory response process of local aneurysms,which may delay the expansion of intracranial aneurysms and reduce the risk of aneurysms rupture.Aspirin,statins,dipeptidyl peptidase-4 inhibitor and so on may be potential medications for IA.This article reviewed the pathophysiology of IA and systematically analyzed related researches of medical therapy for IA.