前列腺素E2的代谢和转运途径及其在肝再生中的作用

Metabolism and transport pathway of prostaglandin E2 and its role in liver regeneration

肝脏是具有再生能力的器官,对于机体稳态的维持至关重要。在病理情况下,例如慢性肝炎、肝硬化等,肝脏再生能力的受损会导致患者肝功能不足甚至肝衰竭,促进肝脏的再生可以改善患者预后。前列腺素E2是一种有生理活性的激素样信使,具有促进组织再生的作用。现针对前列腺素E2的代谢和转运途径及其在肝脏组织再生中的作用机制进行综述,并提出前列腺素E2是参与肝再生过程的重要细胞因子,具有潜在治疗肝损伤的临床应用前景。

The liver is an organ with regenerative capacity and is essential for maintaining the body homeostasis.Under pathological conditions,such as chronic hepatitis,liver cirrhosis and so on,the impairment of liver regeneration can lead to insufficient liver function or even liver failure.Therefore,promoting liver regeneration can improve the patient's prognosis.Prostaglandin E2 is a hormone-like messenger with physiological activity that can promote tissue regeneration.This article reviews the metabolism and transport pathways of prostaglandin E2 and its mechanism of action in liver tissue regeneration,and proposes that prostaglandin E2 is an important cytokine involved in the liver regeneration process,and has potential clinical application prospects for the treatment of liver injury.