三拗片联合常规治疗对感染后咳嗽的疗效与安全性

Efficacy and safety of San’ao tablets combined with conventional treatment for post infectious cough

目的研究三拗片对感染后咳嗽的疗效以及安全性。方法回顾性分析2016年1月~2018年12月5家参研中心呼吸科就诊的150例感染后咳嗽患者,按照随机数字法分为对照组和观察组,每组各75例。对照组采用常规治疗手段进行治疗,观察组在常规治疗手段的基础上加用三拗片进行治疗。比较两组患者治疗前后呼吸道症状评分、症状及体征持续时间、咳嗽症状改善情况、总有效率以及安全性。比较两组患者治疗后的细菌清除率。结果两组治疗前呼吸道症状评分比较差异无统计学意义(P>0.05);观察组治疗后呼吸道症状评分低于治疗前(P<0.05);治疗后,观察组呼吸道症状评分低于对照组(P<0.05)。治疗后,观察组咳嗽、咳痰、气喘及肺部哮音持续时间低于对照组(P<0.05)。观察组治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。观察组患者肺功能明显优于对照组,差异具有统计学意义(P<0.05)。对照组患者不良反应率高于观察组,但差异不具有统计学意义(P>0.05)。观察组细菌总清除率显著高于对照组,差异具有统计学意义(P<0.05)。结论三拗片联合常规治疗手段能够有效改善感染后咳嗽患者呼吸道症状,具有良好的疗效以及安全性,并能够有效提高感染后咳嗽患者的细菌清除率。

Objective To study the efficacy and safety of San’ao tablet in treating cough after infection.Methods A total of 300 patients with infectious respiratory irritation cough in our hospital from January 2016 to December 2018 were enrolled as subjects.According to the conditions,150 patients with viral infectious respiratory tract irritation were divided into the observation group A and the control group A with 75 patients in each group.The control group A was treated with conventional treatment,and the observation group A were treated with San’ao tablets and the basis of conventional treatment.Another 150 patients with bacterial infections respiratory irritation cough were divided into the observation group B and the control group B with 75 cases in each group.The control group B were treated with conventional treatment,and the group B were treated with San’ao tablets the basis of conventional treatment.The respiratory symptoms scores,symptoms as well as signs duration,comparison of cough symptoms,total treatment efficacy and safety before and after treatment were compared in those four groups.The bacterial clearance rate after treatment in the observation group B and the control group B were compared.Results The total effective rate of treatment in the observation group A was 93.33%,which was significantly higher than that in the control group A(73.33%)(P<0.05).The total effective rate of treatment in the observation group B was 96.00%,which was significantly higher than that in the control group B(70.67%)(P<0.05).The score of respiratory symptoms in patients with observation group A and group B were significantly lower than those in control group A and group B after treatment(P<0.05).The adverse reaction rates of the control group A and the control group B were higher than those of the observation group A and the observation group B(P>0.05).The total bacterial clearance rate of the observation group B was 86.67%,which was significantly higher than that of the control group B(76.00%)(P<0.05).Conclusions San’ao tablets combined with conventional treatment can effectively improve the respiratory symptoms in patients with infectious respiratory irritating cough with good efficacy and safety,and can effectively improve the bacterial clearance rate.