金凤丸联合重组人生长激素改善薄型子宫内膜不孕患者子宫内膜容受性

Jinfeng Pill Combined with Recombinant Human Growth Hormone Improved Endometrial Receptivity in Patients with Thin-Endometrial Infertility

目的:观察中成药金凤丸联合重组人生长激素(rhGH)对薄型子宫内膜不孕患者子宫内膜容受性的临床疗效。方法:收集2018年12月—2019年12月在中国人民解放军联勤保障部队第九八〇医院生殖医学科就诊的薄型子宫内膜合并不孕患者80例,采用金凤丸联合rhGH预处理的薄型子宫内膜不孕患者(40例)作为观察组;仅常规处理者作为对照组(40例)。比较2组患者的子宫内膜厚度、子宫内膜分型、子宫内膜下血流分型、临床妊娠率及早期流产率。结果:2组患者取卵年龄、不孕时间、体质量指数(BMI)、基础卵泡刺激素(FSH)、胚胎移植数目、移植胚胎情况及治疗前子宫内膜形态分型、子宫内膜下血流、内膜厚度比较,差异均无统计学意义(均P>0.05)。观察组移植日子宫内膜厚度高于对照组,A型及B型子宫内膜患者妊娠率高于C型子宫内膜患者,Ⅱ型及Ⅲ型子宫内膜血流患者妊娠率高于Ⅰ型子宫内膜血流患者,差异均有统计学意义(P<0.05)。观察组临床妊娠率高于对照组,而流产率低于对照组,差异有统计学意义(P<0.05)。结论:金凤丸联合rhGH可以改善薄型子宫内膜不孕患者的子宫内膜容受性,进而提高临床妊娠率,改善妊娠结局。

Objective:To observe the clinical effect of Jinfeng Pill combined with recombinant human growth hormone(rhGH)on endometrial receptivity in patients with thin endometrium and infertility.Methods:80 infertile patients with thin endometrium in the department of reproductive medicine of our hospital from December 2018 to December 2019 were included.The patients with thin endometrial infertility were treated with Jinfeng Wan and recombinant human growth hormone(40 cases)in the observation group,and only routinely treated(40 cases)in the control group.Endometrial thickness,endometrial typing,subendometrial blood flow,clinical pregnancy rate,and abortion rate were compared between the two groups.Results:There were no significant differences in the age of egg retrieval,infertility,body mass index(BMI),basic follicle stimulating hormone(FSH),number of embryo transfers,embryo transfer,and the endometrial type,subendometrial blood flow type,endometrial thickness before treatment between the two groups(P>0.05).The endometrial thickness of the observation group was higher than that of the control group on the day of transplantation,and the pregnancy rates of type A and type B endometrial patients were higher than that of type C endometrial patients.The pregnancy rate of patients with type II and type III endometrial blood flow was higher than that of patients with type I endometrial blood flow(P<0.05).The clinical pregnancy rate was higher and the miscarriage rate lower in the observation group when compared with the control group(P<0.05).Conclusions:Jinfeng Pill combined with rhGH can improve endometrial receptivity in patients with thin-endometrial infertility,thereby increase clinical pregnancy rate and improve pregnancy outcomes.