与三种呼吸系统疾病关联的男性不育症

Male Infertility Associated with Three Kinds of Respiratory Diseases

男性不育症是一种复杂的临床综合征,任何干扰男性生殖功能的疾病都可能导致男性不育症,这使临床实践中男性不育症病因诊断变得复杂。呼吸系统上皮纤毛与男性精子鞭毛之间存在相似的超微解剖结构,纤毛和鞭毛功能障碍将影响呼吸道黏膜清除功能和精子运动。另外,某些遗传缺陷也可同时导致呼吸系统和男性生殖系统的异常。这类影响男性生育的呼吸系统疾病主要包括原发性纤毛运动障碍、囊性纤维化和Young综合征,介绍这三种疾病的主要临床特点及研究进展,并分析其呼吸系统与生殖系统临床表现之间的异同,以助于加强对这类疾病的认识。对于严重弱精子症患者,临床医生应常规询问呼吸系统病史,对于反复呼吸道感染的患者同样应关注他们的生育问题。

Male infertility is a complex clinical syndrome.Any disease that interferes with male reproductive function may lead to male infertility,which complicates the etiological diagnosis of male infertility in clinical practice.There are similar ultrastructures between the cilia of respiratory system epithelium and the flagellum of male sperm.The dysfunction of cilia and flagellum will affect the clearance function of respiratory tract mucosa and sperm movement.In addition,some of genetic defects can also lead to abnormal function of respiratory system and male reproductive system.Three kinds of respiratory diseases affecting male fertility were primary ciliary dyskinesia,cystic fibrosis and Young′s syndrome.This review introduceds the main clinical characteristics of these diseases and analyzed the differences between the clinical manifestations of respiratory system and reproductive system,which will strengthen the understanding of these diseases.It is suggested that clinicians should routinely inquire about the history of respiratory system for patients with severe asthenospermia,and about the reproductive problem for those patients with recurrent respiratory tract infection.