摘要
The central nervous system(CNS)has very restricted intrinsic regeneration ability under the injury or disease condition.Innovative repair strategies,therefore,are urgently needed to facilitate tissue regeneration and functional recovery.The published tissue repair/regeneration strategies,such as cell and/or drug delivery,has been demonstrated to have some therapeutic effects on experimental animal models,but can hardly find clinical applications due to such methods as the extremely low survival rate of transplanted cells,difficulty in integrating with the host or restriction of blood-brain barriers to administration patterns.Using biomaterials can not only increase the survival rate of grafts and their integration with the host in the injured CNS area,but also sustainably deliver bioproducts to the local injured area,thus improving the microenvironment in that area.This review mainly introduces the advances of various strategies concerning facilitating CNS regeneration.
基金
We express heartfelt thanks to Liwei Zhang(Science China Press)for her kind help and constructive comments.This work was supported by the State Key Program of National Natural Science Foundation of China(grants 31130022,31320103903,31271037)
the National Science and Technology Pillar Program of China(grant 2012BAI17B04)
the International Cooperation in Science and Technology Projects of the Ministry of Science Technology of China(grant 2014DFA30640)
the National 863 Project(grant 2012AA020506)
the National Ministry of Education Special Fund for Excellent Doctoral Dissertation(grant 201356)
the Special Funds for Excellent Doctoral Dissertation of Beijing,China(grant 20111000601)
the Key Project of the Department of Science and Technology of Beijing(grant D090800046609004).
