宣肺化痰通络法对AECOPD危险窗的临床研究

Clinical Observation of Xuanfei Huatan Tongluo Method on AECOPD Risk Window

目的观察宣肺化痰通络法对慢性阻塞性肺疾病急性加重期(AECOPD)危险窗属痰瘀阻肺型患者的影响。方法将120例患者分为观察组和对照组各60例,对照组予沙美特罗氟替卡松粉吸入剂治疗,观察组在常规治疗基础上加用宣肺化痰通络法。治疗14 d后,比较两组临床疗效,治疗前后中医证候积分、肺功能指标水平、凝血功能指标、血液流变学指标,记录患者发生首次急性加重的时间及不良反应情况。结果观察组总有效率为93.33%,明显高于对照组的75.00%(P<0.05);观察组治疗后中医证候积分和肺功能指标水平显著优于对照组(P<0.05);观察组治疗后凝血功能指标、全血高切黏度、全血低切黏度、血浆黏度指标均显著优于对照组(P<0.05);同时观察组发生首次急性加重的时间较对照组明显延长(P<0.05),观察组不良反应发生率显著低于对照组(P<0.05)。结论宣肺化痰通络法可有效缓解AECOPD危险窗患者临床症状,改善肺功能,还能减少血栓前状态的发生,使患者更快过渡到缓解期。

Objective:To observe the effect of Xuanfei Huatan Tongluo method on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with a risk window of phlegm and stasis obstructing the lung.Methods:A total of 120 patients were divided into the observation group and control group,60 cases in each group.The control group was given conventional western medicine treatment,and the observation group was treated with the method of Xuanfei Huatan Tongluo on the basis of conventional treatment.The clinical efficacy of the two groups was compared,the scores of TCM syndromes,pulmonary function index levels,coagulation function indexes,and hemorheology indexes before and after treatment were compared,and the time to the first acute exacerbation and adverse reactions were recorded.Results:The total effective rate of the observation group was93.33%,which was significantly higher than 75.00%of the control group(P<0.05);the observation group′s TCM syndrome scores and lung function index levels after treatment were significantly better than those of the control group(P<0.05);after treatment,the coagulation function indexes,whole blood high shear viscosity,whole blood low shear viscosity,and plasma viscosity indexes of the observation group were significantly better than those of the control group(P<0.05);the occurrence time of the first acute exacerbation in observation group the was significantly longer than that of the control group(P<0.05),and the incidence of adverse reactions in the observation group was significantly lower than that of the control group(P<0.05).Conclusion:Xuanfei Huatan Tongluo method can effectively relieve the clinical symptoms of patients with AECOPD risk window,improve lung function,and reduce the occurrence of prethrombotic state,so that patients can transition to the remission phase faster.