调强放疗和三维适形放疗治疗局部晚期非小细胞肺癌的效果比较

Comparison of the Effects of Intensity-modulated Radiotherapy and Three-dimensional Conformal Radiotherapy in the Treatment of Locally Advanced Non-small Cell Lung Cancer

目的探讨调强放疗(IMRT)、三维适形放疗(3D-CRT)应用于局部晚期NSCLC患者的临床治疗价值。方法选取2018年1月—2019年12月作为本次研究区间,随机选择在此区间内医院收治的98例局部晚期NSCLC患者进行分组研究(随机数字表法)。研究组(n=49)实施IMRT治疗,对照组(n=49)行3D-CRT治疗,两组均根据NSCLC患者实际情况合理制定化疗方案。记录两组近期疗效、放疗相关不良反应发生情况。结果研究组近期总有效率为63.27%、对照组为42.86%,P<0.05;研究组平均靶区剂量、不均匀指数、适形指数均高于对照组(P<0.05);研究组放射性食管炎、放射性肺炎发生率均低于、对照组(P<0.05)。结论应用IMRT治疗局部晚期NSCLC患者有效性、安全性均较优。

Objective To explore the clinical value of intensity-modulated radiotherapy(IMRT)and threedimensional conformal radiotherapy(3D-CRT)in patients with locally advanced NSCLC.Methods The period from January 2018 to December 2019 was selected as the study interval,and 98 patients with locally advanced NSCLC admitted to our hospital in this interval were randomly selected for group study(random number table method).The study group(n=49)was treated with IMRT,and the control group(n=49)was treated with 3D-CRT.Both groups were given reasonable chemotherapy regimens based on the actual conditions of NSCLC patients.The recent curative effect and occurrence of radiotherapy-related adverse reactions were recorded in the two groups.Results The short-term total effective rate of the study group was 63.27%,and that of the control group was 42.86%,P<0.05;the average target dose,inhomogeneity index and conformal index of the study group were higher than those of the control group(P<0.05);the incidence of radiation esophagitis and radiation pneumonia in the study group were lower than those in the control group(P<0.05).Conclusion The effectiveness and safety of IMRT in the treatment of locally advanced NSCLC patients are better.