摘要
卒中后抑郁(post-stroke depression,PSD)是脑卒中最常见的并发症之一,严重影响患者生活质量。然其具体发病机制尚不清楚,考虑到PSD病灶位于脑部,主要累及中枢神经系统,因此神经再生学说一经提出,立即引起国内外学者的重视。然而神经再生需要多因素共同参与、调控,本文主要综合神经递质、神经营养因子、神经内分泌等方面,阐述PSD与神经再生相关的研究进展。
Post stroke depression(PSD)is one of the most common complications of stroke,which seriously affects the quality of life of patients.However,the specific pathogenesis of PSD is still unclear.Considering that PSD is located in the brain and mainly affects the central nervous system,the theory of neurogenesis immediately attracted the attention of scholars at home and abroad since it was proposed.However,neurogenesis is a process that requires joint participation and regulation of multiple factors.In this paper,the progress of research about the relationship between post-stroke depression and neurogenesis is reviewed in aspects of neurotransmitters,neurotrophic factors and neuroendocrine.
作者
贺旭
林赛月
汤艳
赵宏
陈小语
He Xu;Lin Saiyue;Tang Yan;Zhao Hong;Chen Xiaoyu(Department of Anatomy,Yiyang Medical College,Yiyang 413000,China;Department of Integrated Traditional and Western Medicine,Hunan University of Traditional Chinese Medicine,Changsha 410208,China;Department of Anatomy and Histoembryology,Shaoyang University,Shaoyang 422000,China)
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2020年第6期563-567,共5页
Chinese Journal of Histochemistry and Cytochemistry
基金
湖南省自然科学基金青年项目(2018JJ3517)
湖南省教育厅科学研究优秀青年项目(19B441)
湖南省中医药科研项目(201932)
益阳市银城科技人才托举工程项目(益科协通(2020)3号)
湖南中医药大学中西医结合一流学科开放基金项目(2019ZXYJH07)。
关键词
卒中后抑郁
神经再生
5-羟色胺
神经营养因子
Post stroke depression
neurogenesis
5-hydroxytryptamine
neurotrophic factors
