CD4^(+)T细胞分化在类风湿关节炎中的研究进展

CD4^(+)T cell differentiation in rheumatoid arthritis

T细胞功能紊乱,尤其是抗原提呈细胞和CD4^(+)T细胞相互作用导致CD4^(+)T细胞的异常活化,启动适应性免疫应答,在类风湿关节炎患者的滑膜持续炎症、关节软骨及骨破坏中发挥重要作用。辅助性T细胞亚群失衡诱导炎性细胞因子进一步促进滑膜细胞增生、血管翳形成和炎症细胞浸润,在类风湿关节炎免疫病理中起核心作用。了解CD4^(+)T细胞分化及细胞亚群为理解关节炎的发病机制提供了新视点,并有助于发现新的药物靶点。

The dysfunction of T cells,especially the interaction of antigen presenting cells and CD4^(+)T cells,leads to abnormal activation of CD4^(+)T cells and the initiation of adaptive immune response.Dysfunction of the immune system plays an important role in the pathogenesis of rheumatoid arthritis.It is always considered as the central link of synovial continuous inflammation,articular cartilage and bone destruction in rheumatoid arthritis patients.Exploring CD4^(+)T cell differentiation and cell subsets provides a new perspective for understanding of arthritis and helps to identify new drug targets.