龙葵抗肿瘤成分及其作用机制研究进展

Research progress on antitumor components and mechanism of Solanumnigrum L.

龙葵是治疗肿瘤的常用中药,含有多种抗肿瘤活性成分,如龙葵碱、澳洲茄边碱、龙葵酸、澳洲茄碱、澳洲茄胺、去半乳糖替告皂苷、槲皮素、薯蓣皂苷元等,可治疗胃癌、肺癌、大肠癌、乳腺癌、膀胱癌、肝癌、骨肉瘤、前列腺癌等恶性肿瘤。其抗肿瘤作用及机制主要包括抑制增殖生长、阻滞细胞周期、诱导细胞凋亡、抑制上皮-间质转化和转移、逆转耐药、增强放化疗和靶向治疗疗效等。

Solanumnigrum L.is a Chinese medicine commonly used in tumor treatment,which contains a variety of anti-tumor active ingredients,such as solanine,solamargine,solaoiacid,solasonine,solasodine,degalactotigonin,quercetin,diosgenin and so on.It can be used to treat gastric cancer,lung cancer,colorectal cancer,breast cancer,bladder cancer,liver cancer,osteosarcoma,prostate cancer and other malignant tumors.Its anti-tumor mechanisms include inhibition of proliferation and growth,arrest of cell cycle,induction of apoptosis,inhibition of epithelial-stromal transformation and metastasis,reversal of drug resistance,enhancement of radiotherapy,chemotherapy and targeted therapy.