疏肝和胃颗粒治疗肝胃郁热型反流性食管炎疗效观察

Effect of Shugan Hewei Granules on reflux esophagitis of stagnant heat in liver and stomach syndrome

目的评价疏肝和胃颗粒治疗肝胃郁热型反流性食管炎的临床疗效。方法将94例肝胃郁热型反流性食管炎患者随机分为试验组和对照组,每组47例。试验组予生活饮食指导合疏肝和胃颗粒,对照组予生活饮食指导合奥美拉唑。两组疗程均为8周,观察临床疗效、临床症状积分以及胃镜下食管黏膜分级变化情况。结果入组患者94例均完成了8周疗程,其中疗程结束后实际完成胃镜复查76例。试验组临床及胃镜总有效率分别为95.74%、80.00%,对照组分别为76.60%、63.89%,试验组临床疗效及胃镜疗效均优于对照组(P<0.05)。两组治疗后,临床症状积分值均显著降低(P<0.05);组间治疗后临床症状积分差值比较,差异有统计学意义(P<0.05)。两组治疗后,胃镜下食管黏膜炎症分级均明显改善(P<0.05);组间治疗后比较,胃镜下食管黏膜炎症分级差异有统计学意义(P<0.05)。结论疏肝和胃颗粒可以明显提高肝胃郁热型反流性食管炎的临床疗效,改善临床症状,减轻食管黏膜炎症。

Objective To evaluate the clinical effect of Shugan Hewei Granules on reflux esophagitis of stagnant heat in the liver and stomach syndrome.Methods Totally 94 patients suffering from reflux esophagitis of stagnant heat in the liver and stomach syndrome were randomly divided into test group(n=47)and control group(n=47).The test group was treated with Shugan Hewei Granules and the control group was treated with omeprazole;the course of treatment in both groups was 8 weeks,and the clinical therapeutic effect,clinical symptom score and esophageal mucosal grading under gastroscopy were observed.Results All 94 enrolled patients completed the 8-week course of treatment,and 76 of them actually completed the gastroscopy review after the course of treatment.The total effective rates of the treatment and improvement of esophageal mucosal inflammation under gastroscopy in the test group were 95.74%and 80.005%respectively,while those in the control group were 76.60%and 63.89%respectively.The clinical therapeutic effect and the improvement of esophageal mucosal inflammation under gastroscopy in the test group were better than those in the control group(P<0.05).After treatment,the clinical symptom scores of the two groups decreased significantly(P<0.05),and there was significant difference in the clinical syndrome scores between the two groups after treatment(P<0.05).After treatment,the grade of esophageal mucosal inflammation significantly improved in both groups(P<0.05),and there was significant difference in the grade of esophageal inflammation under gastroscopy between the two groups after treatment(P<0.05).Conclusion Shugan Hewei granules has obvious clinical effect on reflux esophagitis of stagnant heat in the liver and stomach syndrome,as it can improve clinical symptoms and reduce esophageal mucosal inflammation.