中药抗哮喘气道炎症机制的研究进展

Research progress of anti-inflammation mechanism in asthmatic airway with traditional Chinese medicine

综述近年来中药治疗哮喘气道炎症机制的研究进展。中药复方或单味中药及其提取物可通过适应性免疫调节、抑制抗原呈递、固有免疫调节、抑制氧化应激、提高抗氧化能力、抑制NLRP3炎症小体形成、抑制炎症反应通路等,实现治疗哮喘的抗炎效应。同时通过网络药理学、高效液相色谱、基因组学、蛋白质组学等研究显示有效成分间的相互作用,进一步揭示中药多靶点多通路治疗哮喘气道炎症的机制。

This paper sumarizes the research progress about the mechanism of traditional Chinese medicine in treating asthmatic airway inflammation in recent years.Compound or single traditional Chinese medicine and its extracts can treat asthmatic airway inflammation through adaptive immune regulation,inhibition of antigen presentation,innate immune regulation,inhibition of oxidative stress,improvement of antioxidant capacity,inhibition of NLRP3 inflammasome formation,and inhibition of inflammatory response pathways.At the same time,studies on network pharmacology,high performance liquid chromatography,genomics,proteomics and other studies have shown the interaction between active ingredients,and further revealed the mechanism of multi-target and multi-channel treatment of asthma airway inflammation by traditional Chinese medicine.