摘要
Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future.
基金
the National Institutes of Health(CA226303to TCH)
the U.S.Department of Defense(OR130096 to JMW)
the Scoliosis Research Society(TCH and MJL)
the Pritzker-Northshore Fellowship at The University of Chicago
the Medical Scientist Training Program of the National Institutes of Health(T32 GM007281)
The University of Chicago Cancer Center Support Grant(P30CA014599)
the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1 TR000430
the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund。
