狼毒大戟根中的萜类成分研究

Terpenoids Isolated from Roots of Euphorbia fischeriana

目的:研究狼毒大戟Euphorbia fischeriana根中的萜类成分。方法:利用硅胶、MCI、ODS、Sephadex LH-20柱色谱及半制备高效液相色谱法(HPLC)等分离手段对狼毒大戟根中的萜类成分进行分离纯化,根据理化性质、波谱学数据分析鉴定化合物结构。结果:从狼毒大戟根的80%丙酮提取物中分离鉴定了7个萜类化合物,包括5个二萜类化合物和2个三萜类化合物,分别鉴定为7-羰基脱氢松香酸(1)、trogopteroid F(2)、陶塔二酚(3)、18-羟基弥罗松酚(4)、19-羟基弥罗松酚(5)、环木波罗-22-烯-3β,25-二醇(6)和羽扇豆醇(7)。结论:除了化合物6和7,其余化合物均为首次从狼毒大戟中分离得到。

Objective:To investigate the terpenoids from the roots of Euphorbia fischeriana.Methods:The compounds were isolated and purified by silica gel,MCI,ODS,Sephadex LH-20,and semi-preparative high performance liquid chromatography(HPLC)repeatedly,and elucidate according to their physicochemical properties and spectroscopics.Results:Seven known compounds,including five diterpenoids and two triterpenoids were isolated from 80%acetone extracts of roots of E.fischeriana and identified as 7-oxodehydroabietic acid(1),trogopteroid F(2),totaradiol(3),18-hydroxyferruginol(4),19-hydroxyferruginol(5),cycloart-22-ene-3β,25-diol(6)and lupeol(7).Conclusion:Except for compounds 6 and 7,all of the compounds were isolated from this genius for the first time.