荷叶碱药理作用及机制研究进展

Progress in Pharmacology Research and Mechanisms of Nuciferine

荷叶碱提取自睡莲科植物莲Nelumbo nucifera Gaertn.的干燥叶,是荷叶中的指征成分和主要的药理活性成分。其具有广泛的药理活性,可产生调血脂、降血糖、抗炎、抗癌等多种药理作用,且不良反应小,具有一定开发价值。对荷叶碱的潜在药理作用及其机制进行总结,针对其显著的调脂和降糖作用进行了重点介绍,并对未来可研究的方向进行展望。

Nuciferine,a compound extracted from the dry leaves of Nelumbo nucifera Gaertn.,is an indicative and major pharmacological active component.It not only has a vast range of pharmacological activities,such as lipid-decreasing,hypoglycemic,anti-inflammatory,anti-tumor activities,also has an advantage on its low toxic and side effects.It is considered having a great development prospect.In this paper,the potential pharmacological activities and its mechanisms are summarized respectively,and the notable lipid-lowering and hypoglycemic effects were emphatically introduced,as well as the future research direction is prospected.