自体富血小板血浆治疗膝骨关节炎的临床效果

Clinical effect of autologous platelet-rich plasma in the treatment of knee osteoarthritis

目的探索自体富血小板血浆治疗膝骨关节炎的临床效果。方法选择80例膝骨关节炎患者为研究对象,根据单双号随机将其分为对照组和观察组,每组40例。对照组采用关节腔内注射玻璃酸钠法治疗,观察组采用自体富血小板血浆治疗。比较两组的治疗效果。结果治疗12周后,观察组的Lysholm评分、膝关节活动度优于对照组(P<0.05)。治疗2、12周后,观察组的VAS评分均低于对照组(P<0.05)。治疗12周后,观察组的SP、5-HT、PGE2、IL-1β、TNF-α水平均低于对照组(P<0.05)。观察组的并发症总发生率低于对照组(P<0.05)。结论自体富血小板血浆治疗膝骨关节炎患者的效果显著。

Objective To explore the clinical effect of autologous platelet-rich plasma in the treatment of knee osteoarthritis.Methods Eighty patients with knee osteoarthritis were selected as the research objects and randomly divided into control group and observation group according to odd-even number,with 40 cases in each group.The control group was treated with intraarticular injection of sodium hyaluronate,and the observation group was treated with autologous platelet-rich plasma.The therapeutic effect of the two groups was compared.Results After 12 weeks of treatment,Lysholm score and range of motion of knee joint in the observation group were better than those in the control group(P<0.05).After 2 and 12 weeks of treatment,the VAS scores of the observation group were lower than those of the control group(P<0.05).After 12 weeks of treatment,the levels of SP,5-HT,PGE2,IL-1βand TNF-αin the observation group were lower than those in the control group(P<0.05).The total incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion Autologous platelet-rich plasma is effective in the treatment of patients with knee osteoarthritis.