尼莫地平联合丹参川芎嗪对妊娠期高血压疾病患者凝血功能、Hcy、PLGF水平的影响

Effects of nimodipine combined with salviae miltiorrhizae and ligustrazine on coagulation function,Hcy and PLGF levels in patients with hypertensive disorder complicating pregnancy

目的探讨尼莫地平联合丹参川芎嗪对妊娠期高血压疾病患者凝血功能、同型半胱氨酸(Hcy)、胎盘生长因子(PLGF)水平的影响。方法将88例妊娠期高血压疾病患者随机分为对照组和观察组,各44例。对照组在硫酸镁+拉贝洛尔治疗基础上应用尼莫地平治疗,观察组则在对照组治疗基础上联合丹参川芎嗪治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,两组舒张压、收缩压、FIB及Hcy水平均降低,PT及APTT均延长,PLGF水平均升高,且观察组优于对照组(P<0.05)。结论尼莫地平联合丹参川芎嗪治疗妊娠期高血压疾病,能显著提高临床效果,改善患者的凝血功能及Hcy、PLGF水平。

Objective To explore the effects of nimodipine combined with salviae miltiorrhizae and ligustrazine on coagulation function,homocysteine(Hcy)and placental growth factor(PLGF)levels in patients with hypertensive disorder complicating pregnancy.Methods Eighty-eight patients with hypertensive disorder complicating pregnancy were randomly divided into control group and observation group,with 44 cases in each group.The control group was treated with nimodipine on the basis of magnesium sulfate+labetalol,while the observation group was treated with salviae miltiorrhizae and ligustrazine on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the diastolic blood pressure,systolic blood pressure,FIB and Hcy levels of the two groups decreased,PT and APTT prolonged,PLGF level increased,and those of the observation group were better than the control group(P<0.05).Conclusion Nimodipine combined with salviae miltiorrhizae and ligustrazine in the treatment of hypertensive disorder complicating pregnancy can significantly improve the clinical efficacy,and ameliorate coagulation function and Hcy,PLGF levels of patients.