不同药物在反流性食管炎治疗中的成本效果

Cost-effectiveness of Different Drugs in the Treatment of Reflux Esophagitis

目的对比反流性食管炎患者采用2种不同的质子泵抑制剂类药物进行治疗的成本效果。方法选择2016年3月至2019年3月在我院接受治疗的84例反流性食管炎患者,以随机分组法分为对照组(42例)和观察组(42例)。对照组采用埃索美拉唑进行治疗,观察组采用奥美拉唑进行治疗。比较两组药物治疗效果、不良反应发生情况、食管炎症状消失时间和住院时间、用药前后生活质量和心理状态、治疗的成本效果以及患者的满意度。结果观察组治疗总有效率略低于对照组,差异无统计学意义(P>0.05)。观察组不良反应总发生率略低于对照组,差异无统计学意义(P>0.05)。两组食管炎症状消失时间和住院时间基本相当,差异均无统计学意义(P>0.05)。用药前,两组患者的SF-36、HAMA、MAHD评分比较,差异无统计学意义(P>0.05);用药后,两组患者的SF-36评分均高于用药前,HAMA和MAHD评分均低于用药前,且观察组变化幅度更大,差异均有统计学意义(P<0.05)。观察组治疗的成本效果远低于对照组,差异有统计学意义(P<0.05)。观察组患者的满意度高于对照组,差异有统计学意义(P<0.05)。结论反流性食管炎患者采用奥美拉唑进行治疗不会增加药物不良反应,病情控制时间和控制效果与埃索美拉唑相当,但能够明显提升治疗的成本效果,减轻患者的经济压力,使其保持良好的生活质量和心理状态,且其对治疗方案的满意度较高。

Objective To compare the cost-effectiveness of two different proton pump inhibitors in the treatment of reflux esophagitis.Methods From March 2016 to March 2019,84 patients with reflux esophagitis were randomly divided into control group(42 cases)and observation group(42 cases).The control group was treated with esomeprazole,while the observation group was treated with omeprazole.The total effective rate of drug observation,adverse drug reactions,disappearance time of symptoms of esophagitis and hospitalization time,quality of life and mental state score before and after treatment,costeffectiveness of treatment and satisfaction with treatment plan were compared between the two groups.Results The total effective rate of the observation group was slightly lower than the control group,and the difference was not statistically significant(P>0.05).The total incidence of adverse reactions in the observation group was slightly lower than that in the control group,and the difference was not statistically significant(P>0.05).The disappearance time of esophagitis symptoms and the length of stay in the two groups were basically the same,and the difference was not statistically significant(P>0.05).Before medication,the SF-36,HAMA and MAHD scores of the two groups were not statistically different(P>0.05);after medication,the SF-36 scores of the two groups were higher than before medication,and the HAMA and MAHD scores were both it was lower than before medication,and the observation group had a larger change range,and the differences were statistically significant(P<0.05).The cost-effectiveness of treatment in the observation group was much lower than that of the control group,and the difference was statistically significant(P<0.05).The satisfaction of patients in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Omeprazole does not increase adverse drug reactions in patients with reflux esophagitis,the control time and effect of omeprazole are comparable to those of esomeprazole.However,omeprazole can significantly improve the cost-effectiveness of treatment,reduce the pressure of patients,maintain their quality of life and psychological state,and improve their satisfaction with the treatment plan.