非诺贝特结合小剂量苯溴马隆治疗痛风患者的临床疗效

Clinical Efficacy Fenofibrate combined with Small Dose of Benzbromarone in the Treatment of Gout

目的评估非诺贝特结合小剂量苯溴马隆治疗痛风患者的临床疗效。方法 2017年2月至2020年6月,选取本院接收的192例痛风患者作为此次研究对象,双盲法将其分为单一组和联合组,各96例。单一组采用单一苯溴马隆治疗,联合组采用非诺贝特结合小剂量苯溴马隆治疗。比较两组治疗前后空腹血尿酸、肌酐、血脂水平、疼痛情况和痛风急性发作次数。结果治疗后,联合组的空腹血尿酸、肌酐、总胆固醇和三酰甘油水平明显低于单一组(P<0.05);同时,联合组的视觉模拟评分法(VAS)评分也明显低于单一组,其痛风急性发作次数明显少于单一组(P<0.05)。结论在痛风患者中采用非诺贝特结合小剂量苯溴马隆治疗,能进一步降低其空腹血尿酸、肌酐和血脂水平,并减轻疼痛,减少疼痛急性发作次数。

Objective To evaluate the clinical efficacy of fenofibrate combined with small dose of benzbromarone in the treatment of gout.Methods From February 2017 to June 2020,192 patients with gout admitted to our hospital were selected as the subjects of this study,and were divided into single group and combined group by double-blind method,with 96 patients in each group.The single group was treated with single benzbromarone,and the combination group was treated with fenofibrate combined with small dose benzbromarone.The fasting blood uric acid,creatinine,blood lipid levels,pain and the number of acute attacks of gout were compared between the two groups before and after treatment.Results After treatment,the fasting blood uric acid,creatinine,total cholesterol and triacylglycerol levels of the combined group were significantly lower than those of the single group(P<0.05);at the same time,the Visual Analogue Scale(VAS)score of the combined group was also significantly lower than that of the single group.The number of acute attacks of gout was significantly less than that of the single group(P<0.05).Conclusion The use of fenofibrate combined with small dose benzbromarone treatment in gout patients can further reduce their fasting blood uric acid,creatinine and blood lipid levels,reduce pain,and reduce the number of acute episodes of pain.