乳腺间质CD_(34)和平滑肌肌动蛋白免疫组化检测在乳腺癌诊断中的应用

Application of Immunohistochemical Detection of CD_(34) and Smooth Muscle Actin in the Diagnosis of Breast Cancer

目的针对乳腺间质CD_(34)和平滑肌肌动蛋白免疫组化检测乳腺癌价值进行分析。方法在2018年5月至2019年5月,对150例乳腺疾病患者进行回顾性对比分析,根据患者病理组织结果分组,分为观察组(90例,乳腺癌)和对照组(60例,乳腺良性病变),采用乳腺间质CD_(34)和平滑肌肌动蛋白免疫组化检测,比较两组患者CD_(34)、平滑肌肌动蛋白阳性诊出率情况,分析乳腺间质CD_(34)和平滑肌肌动蛋白与乳腺癌疾病相关性。结果观察组患者CD_(34)阳性诊出率(81.11%)明显高于对照组(13.33%),平滑肌肌动蛋白阳性诊出率(75.55%)明显高于对照组(15.00%)(P<0.05)。CD_(34)、平滑肌肌动蛋白阳性表达与患者TNM分期、淋巴结转移、超声BI-RADS分级具有明显相关性。结论乳腺间质CD_(34)、平滑肌肌动蛋白免疫组化检测在乳腺癌患者疾病诊断和治疗中具有一定的诊断价值,且能够评估患者疾病发展情况。

Objective To analyze the value of immunohistochemical detection of CD34 and smooth muscle actin in breast cancer.Method From May 2018 to may 2019,150 patients with breast diseases were retrospectively analyzed and divided into the observation group(90 cases,breast cancer)and the control group(60 cases,benign breast lesions)according to the pathological results of the patients.The positive detection rates of CD34 and smooth muscle actin were compared between the two groups,objective to analyze the correlation between breast stromal CD34 and smooth muscle actin and breast cancer.Results The positive rate of CD34 index in the observation group was 81.11%,which was significantly higher than in the control group(13.33%)(P<0.05).The positive rate of actin content in the observation group was 75.55%,which was significantly higher than in the control group(15.00%)(P<0.05).The positive expression of CD34 and smooth muscle actin was significantly correlated with TNM stage,lymph node metastasis and BI-RADS grade.Conclusion Immunohistochemical detection of breast stromal CD34 and smooth muscle actin has a certain diagnostic value in the diagnosis and treatment of breast cancer patients,and can evaluate the disease development of patients,which can be used in clinical practice.