急性冠状动脉综合征的发病机制及治疗进展

Progress in mechanisms and treatment of acute coronary syndrome

现今我国心血管疾病患病率及病死率仍处于上升阶段,急性冠状动脉综合征(ACS)是心血管疾病中最严重的类型,可导致心律失常、心力衰竭甚至猝死。近年来,随着腔内影像学技术的进展和新兴研究结果的公布,ACS发病机制的研究获得了新进展,根据发病机制可将ACS分为4类:斑块破裂伴随炎症;斑块破裂不伴炎症;斑块侵蚀;冠状动脉痉挛。根据发病机制对ACS进行分类治疗,对降低ACS患者心血管疾病残余风险,提高生存质量和预后,以及减轻我国心血管疾病负担具有重要意义。本文将对ACS的发病机制及治疗展开综述。

Nowadays,the prevalence and mortality of cardiovascular disease are still on the rise.Acute coronary syndrome(ACS)is the most serious type of cardiovascular disease,which can lead to arrhythmia,heart failure,and even sudden death.In recent years,with the technological advances of intracavitary imaging and the emerging research results,new progress has been made in the pathogenesis of ACS.According to the pathogenesis,ACS is divided into four categories:plaque rupture with inflammation,plaque rupture without inflammation,plaque erosion,and coronary artery spasm.It is of great significance to classify and treat ACS according to the pathogenesis for reducing the residual risk of cardiovascular disease,improving the living quality and prognosis of patients with ACS,and reducing the burden of cardiovascular disease in China.This article reviews the pathogenesis and treatment of ACS.