小脑卒中患者认知域受损特点及影像学研究进展

Advances in Clinical and Imaging Research of Cognitive Dysfunction in Patients with Cerebellar Stroke

小脑情感认知综合征(cerebellar cognitive affective syndrome,CCAS)指小脑病变患者所出现的认知障碍,其特征表现为执行、视空间、语言障碍及人格的改变。单纯性小脑卒中患者可出现CCAS,且基于体素的结构影像研究验证了认知障碍的发生及受损特点与病灶部位密切相关。此外,功能影像研究提示其发病机制可能由于脑网络结构改变引起的大脑-小脑环路受损。本文对小脑卒中患者受损的认知域及其影像学研究进展做一简要概述,以提高临床认识。

Cerebellar cognitive affective syndrome(CCAS)is characterized by executive,visuospatial,language dysfunction and personality changes in cerebellar stroke patients.Voxelbased morphometry studies in simple cerebellar stroke patients showed that CCAS was closely related to the location of lesions.Furthermore,functional imaging studies suggested that this mechanism of CCAS may be cerebrum-cerebellar loop damage.To improve clinical understanding,this review summarized the features of cognitive impairment in different domains in cerebellar stroke patients and the advances in imaging research in CCAS.