前列地尔联合百令胶囊治疗慢性肾脏病的临床研究

Clinical study of alprostadil combined with Bailing Capsule in treatment of chronic kidney disease

目的探讨前列地尔联合百令胶囊治疗慢性肾脏病患者的临床疗效。方法选取2016年4月—2019年4月喀什地区第一人民医院98例早期慢性肾脏病患者作为研究对象,根据随机数字表法将受试者分为对照组和观察组,每组各49例。对照组患者温水送服百令胶囊,2.5 g/次,3次/d。观察组在对照组的基础上将2 mL前列地尔注射液加入到0.9%的氯化钠20 mL中静脉推注,1次/d。两组均连续治疗1个月。观察两组患者的临床疗效,同时比较两组治疗前后的肾功能指标和炎性因子水平。结果治疗后,对照组和观察组的总有效率分别为75.51%、91.84%,两组总有效率比较存在统计学差异(P<0.05)。治疗后,两组各肾功能指标肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白定量(Upro)均显著降低,肾小球滤过率评估值(eGFR)显著升高(P<0.05),且观察组各指标显著优于对照组(P<0.05)。治疗后,两组血清肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-18水平均明显降低,且观察组低于对照组(P<0.05)。结论前列地尔联合百令胶囊可有效改善慢性肾脏病患者的肾功能,调节免疫,疗效安全显著,对促进早期慢性肾脏病患者病情康复具有积极意义。

Objective To investigate the effect of alprostadil combined with Bailing Capsule in treatment of chronic kidney disease.Methods A total of 98 patients with early chronic kidney disease in the First People’s Hospital of Kashgar from April 2016 to April2019 were selected as the research objects,and the subjects were divided into the control group and the observation group according to the random number table method,with 49 patients in each group.Patients in the control group were po administered with Bailing Capsules with warm water,2.5 g/time,three times daily.Patients in the observation group were iv administered with Alprostadil injection on the basis of the control group,2 mL of Alprostadil injection was added to 0.9%normal saline 20 mL,once per day.Both groups were treated continuously for 1 month.The clinical efficacy of the two groups was observed,and the renal function and inflammatory level of the two groups were compared before and after treatment.Results After treatment,the total effective rate of the control group and the observation group was 75.51%and 91.84%,respectively,and the total effective rate of the two groups was statistically different(P<0.05).After treatment,the levels of Scr,BUN,and Upro at 24 h were significantly decreased,and the evaluation value of eGFR was significantly increased(P<0.05),and the indexes of the observation group were significantly better than the control group(P<0.05).After treatment,the levels of serum TNF-α,hs-CRP and IL-18 in the two groups were significantly reduced,and the observation group was significantly lower than the control group(P<0.05).Conclusion Alprostadil combined with Bailing Capsules can effectively improve the renal function of patients with chronic kidney disease,regulate the immune system,and have a safe and significant effect,which is of positive significance for promoting the rehabilitation of patients with early chronic kidney disease.