蓝芩口服液联合阿莫西林克拉维酸钾分散片治疗儿童急性扁桃体炎的效果及对细胞免疫因子的调控

Effect of Lanqin Oral Liquid combined with Amoxicillin and Clavulanate Potassium Dispersible Tablets in treatment of acute tonsillitis in children and its regulation of cellular immune factors

目的探讨分析蓝芩口服液联合阿莫西林克拉维酸钾分散片治疗儿童急性扁桃体炎的疗效及对患儿血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、可溶性白细胞介素-2受体(sIL-2R)水平的影响。方法选择2017年1月—2018年7月北京市石景山区妇幼保健院收治的急性扁桃体炎患儿192例作为研究对象,将患儿随机分为对照1组(n=63)、对照2组(n=64)和观察组(n=65)。对照1组患儿给予阿莫西林克拉维酸钾分散片,3~7岁患儿1片/次;8~12岁患儿1.5片/次;>12岁患儿2片/次,3次/d。治疗7 d为1个疗程。对照2组患儿给予蓝芩口服液,3~7岁患儿1支/次;8~12岁患儿,1.5支/次;>12岁患儿2支/次,3次/d,治疗7 d为1个疗程。观察组患儿的治疗方案为蓝芩口服液联合阿莫西林克拉维酸钾分散片,服用方案与对照组相同。治疗7 d为1个疗程。观察3组患者的临床疗效、退热时间、症状改善时间及复发率,同时比较3组治疗前后的IL-2、IL-6及sIL-2R水平。结果治疗后,观察组患儿临床治疗总有效率为95.38%,明显高于对照1组的84.13%和对照2组的81.25%,差异有统计学意义(P<0.05)。治疗后,观察组患儿退热时间、症状改善时间及复发率均显著低于对照1组和对照2组,差异有统计学意义(P<0.05);对照1组与对照2组在症状改善时间方面具有显著性差异(P<0.05)。治疗后,3组患儿血清IL-2、IL-6以及sIL-2R水平均较治疗前显著降低(P<0.05);且治疗后观察组患儿血清IL-2、IL-6以及SIL-2水平显著低于对照1组和对照2组,差异均具有统计学意义(P<0.05)。结论蓝芩口服液联合芩口服液和阿莫西林克拉维酸钾治疗急性扁桃体炎可有效促进疾病恢复,改善机体免疫能力,值得临床推广。

Objective To investigate the effect of Lanqin Oral Liquid combined with Amoxicillin and Clavulanate Potassium Dispersible Tablets in treatment of acute tonsillitis in children and its effect on the serum levels of interleukin-2(IL-2),interleukin-6(IL-6)and soluble interleukin-2 receptor(SIL-2 R)in children.Methods A total of 192 children with acute tonsillitis admitted to Maternal and Child Health Hospital of Shijingshan District from January 2017 to July 2018 were selected as the research objects and randomly divided into control group 1(n=63),control group 2(n=64)and observation group(n=65).Children in control group 1 were given Amoxicillin and Clavulanate Potassium Dispersible Tablets,1 tablet/time for 3—7 years old children,1.5 tablets/time for children aged 8—12 years,children older than 12 years old took 2 tablets/time,and the use frequency was three times daily.Children in control group 2 were given Lanqin Oral Liquid,1 branch/time for 3—8 years old children,1.5 branch/time for 8—12 years old children,children order than 12 years old took 2 branch/time,the use frequency was three times daily,and treatment duration was 7 days.The treatment regimen of the children in the observation group was Lanqin Oral Liquid combined with Amoxicillin and Clavulanate Potassium Dispersible Tablets,which was the same as that of the control group.One course of treatment lasted for 7 days.After treatment,the clinical efficacy,antifebrile duration,symptom improvement time,and recurrence rate of patients in the three groups were observed,and the levels of IL-2,IL-6 and SIL-2 R in the three groups were compared before and after treatment.Results After treatment,the total effective rate of clinical treatment in the observation group was 95.38%,significantly higher than 84.13%in control group 1 and 81.25%in control group 2,with statistically significant difference(P<0.05).After treatment,the antifebrile time,symptom improvement time,and recurrence rate of the children in the observation group were significantly lower than those in the control group 1 and 2,with statistically significant differences(P<0.05).There was significant difference in symptom improvement time between control group 1 and control group 2(P<0.05).After treatment,serum levels of IL-2,IL-6,and sIL-2 R were significantly lower in the three groups than before treatment(P<0.05).Moreover,the serum levels of IL-2,IL-6 and sIL-2 R in the observation group were significantly lower than those in the control group 1 and 2 after treatment,with statistically significant differences(P<0.05).Conclusion Lanqin oral liquid combined with Lanqin Oral Liquid combined with Amoxicillin and Clavulanate Potassium Dispersible Tablets in treatment of acute tonsillitis can effectively promote the recovery of disease and improve the immune ability of the body,which is worthy of clinical promotion.