芪苈强心胶囊联合米力农治疗慢性心力衰竭的临床研究

Clinical study of Qiliqiangxin Capsules combined with milrinone in treatment of chronic heart failure

目的评价芪苈强心胶囊联合米力农治疗慢性心力衰竭的临床疗效。方法选取2018年1月—2020年6月内蒙古包钢医院慢性心力衰竭患者140例作为研究对象,随机将患者分为对照组和观察组,每组各70例。对照组以米力农注射液0.5μg/(kg·min)持续泵入72 h,继以0.5μg/(kg·min)每日1次泵入,共4 d。观察组在对照组治疗基础上口服芪苈强心胶囊,3粒/次,3次/d。两组治疗疗程均为7 d。观察两组患者的临床疗效,同时比较两组治疗前后的脑钠肽(BNP)、N末端B型利钠肽原(NT-proBNP)、高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、胱抑素C(Cys-C)水平、左室射血分数(LVEF)和左室舒张末期内径(LVED)。结果治疗后,对照组和观察组的总有效率分别为85.7%和97.1%;两组的总有效率差异有统计学意义(P<0.05)。治疗后,两组BNP、NT-proBNP、hs-CRP、IL-6、Cys-C及LVED水平均显著下降,LVEF显著升高(P<0.05),且观察组上述指标显著优于对照组,差异具有统计学意义(P<0.05)。结论芪苈强心胶囊联合米力农治疗慢性心力衰竭疗效显著,且耐受性较好,具有临床应用及推广价值。

Objective To evaluate the clinical effect of Qiliqiangxin Capsules combined with milrinone in treatment of chronic heart failure.Methods A total of 140 patients with chronic heart failure from January 2018 to June 2020 in Baogang Hospital of Inner Mongolia were selected as the research subjects,patients were randomly divided into control group and observation group,with 70 patients in each group.Patients in the control group were continuously pumped with Milrinone Injection of 0.5 g/(kg·min)for 72 h,and continued to be pumped every once for 4 days.Patients in the observation group were po administered with Qiliqiangxin Capsules on the basis of control group,3 grains/time,three times daily.The course of treatment in both groups was 7 days.The clinical efficacy of two groups was observed,and the levels of BNP,NT-proBNP,hs-CRP,IL-6,Cys-C,and LVEF,LVED before and after treatment were compared.Results After treatment,the total effective rate of the control group and the observation group was85.7%and 97.1%,respectively,the total effective rate difference between two groups was statistically significant(P<0.05).After treatment,the levels of BNP,NT-proBNP,hs-CRP,IL-6,Cys-C,and LVED in two groups were significantly decreased,but LVEF was significantly increased(P<0.05).After treatment,the above indexes in the observation group were significantly better than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Qiliqiangxin Capsules combined with milrinone in treatment of chronic heart failure is effective,and tolerability is good,with clinical application and promotion value.