非酒精性脂肪性肝病与胃肠功能紊乱关系的研究进展

Research Progress on the Relationship between Non-alcoholic Fatty Liver Disease and Gastrointestinal Dysfunction

非酒精性脂肪性肝病(Non-alcoholic fatty liver disease,NAFLD)是指除外酒精和其他明确的肝损害因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征。根据流行病学调查,NAFLD已成为危害人类健康的重要肝病之一,越来越多的研究显示,NAFLD与胃肠功能紊乱(Functional gastrointestinal disorders,FGID)(肠-肝轴、内分泌激素)关系密切,文章概述NAFLD与FGID的相互关系,为临床指导和治疗提供重要的理论依据。

Non-alcoholic fatty liver disease(NAFLD) refers to a clinicopathological syndrome caused by alcohol and other definite liver damage factors, which is characterized by diffuse hepatocyte bullous fat. According to epidemiological investigation, NAFLD has become one of the important liver diseases endangering human health. More and more studies have shown that NAFLD is closely related to functional gastrointestinal disorders(FGID)(intestinal-hepatic axis, endocrine hormones). This paper summarizes the relationship between NAFLD and FGID and provides important theoretical basis for clinical guidance and treatment.