甲强龙冲击治疗小儿神经免疫性疾病的临床疗效观察

Observation on the clinical effect of methylprednisolone impulse in treating children neuroimmune diseases

目的探讨甲强龙冲击治疗小儿神经免疫性疾病的疗效、不良反应及对患儿住院时间、免疫功能的影响。方法选取2018年7月至2019年7月本院收治的105例小儿神经免疫性疾病患儿为研究对象,按照随机数表法分为对照组(n=52)与观察组(n=53)。对照组给予地塞米松磷酸钠治疗,观察组给予甲强龙冲击治疗后改用醋酸泼尼松片,比较两组治疗效果、住院时间、免疫功能指标血清免疫球蛋白G(IgG)、IgM、IgA、不良反应。结果观察组总有效率为90.57%,高于对照组的71.15%(P<0.05);治疗后,两组血清IgG、IgM、IgA水平降低,且观察组低于对照组(P<0.05);观察组住院时间为(40.69±5.52)d,短于对照组的(53.76±7.81)d(P<0.05);观察组不良反应发生率为5.66%,低于对照组的19.23%(P<0.05)。结论甲强龙冲击治疗小儿神经免疫性疾病疗效确切,能改善患儿的免疫功能,缩短住院时间,且不良反应少,安全可靠,具有较高的临床应用价值。

Objective To explore the efficacy,adverse reactions,and effects on the length of hospitalization and immune function in children with neuropresence of methylprednisolone.Methods From July 2018 to July 2019,105 children with neuroimmune diseases in our hospital were selected as study subjects,and they were divided into the control group(n=52)and the observation group(n=53)according to the random number table method.The control group was treated with dexamethasone sodium phosphate,and the observation group was switched to prednisone acetate after treatment with methylprednisolone.The treatment effect,hospitalization time,immune function indicators,serum immunoglobulin G(IgG),IgM,IgA,adverse reactions were compared between two groups.Results The total effective rate in the observation group was 90.57%,which was higher than 71.15%in the control group(P<0.05);after treatment,the serum IgG,IgM,and IgA levels of the two groups decreased,and the observation group was lower than the control group(P<0.05);the hospital stay in the group was(40.69±5.52)d,which was less than(53.76±7.81)d in the control group(P<0.05);the incidence of adverse reactions in the observation group was 5.66%,which was lower than 19.23%in the control group(P<0.05).Conclusion Methylprednisolone shock is effective in treating neuroimmune diseases in children.It can improve the immune function of children,shorten the hospital stay,has fewer adverse reactions,is safe and reliable,and has high clinical application value.