急诊PCI结合rh-BNP对急性前壁心肌梗死患者心室胶原重塑相关指标的影响

Effect of emergency PCI combined with rh-BNP on ventricular collagen remodeling in patients with acute anterior myocardial infarction

目的观察急诊经皮冠脉介入治疗(PCI)结合重组人脑利钠肽(rh-BNP)对急性前壁心肌梗死患者心室胶原重塑相关指标的影响。方法回顾性分析2017年3月至2019年2月于本院接受治疗的80例急性前壁心肌梗死患者的临床资料,其中接受急诊PCI治疗的40例作为对照组,接受急诊PCI结合rh-BNP治疗的40例作为观察组。比较两组治疗前后心功能指标[左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)]与心室胶原重塑相关指标[Ⅲ型前胶原(PCⅢ)、Ⅰ型前胶原羧基端肽(PⅠCP)、基质金属蛋白酶组织抑制剂(TIMP-1)]水平。结果治疗后,两组LVEF提高,LVEDD、LVESD均降低,且观察组LVEF高于对照组,LVEDD、LVESD均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组PCⅢ、PⅠCP水平降低,TIMP-1水平升高,且观察组PCⅢ、PⅠCP水平低于对照组,TIMP-1水平高于对照组,差异有统计学意义(P<0.05)。结论急诊PCI结合rh-BNP可改善急性前壁心肌梗死患者心室胶原重塑相关指标,提高心功能。

Objective To observe the effect of emergency percutaneous coronary intervention(PCI)combined with recombinant human brain natriuretic peptide(rh-BNP)on ventricular collagen remodeling in patients with acute anterior wall myocardial infarction(AMI).Methods The clinical data of 80 cases patients with acute anterior wall myocardial infarction treated in our hospital from March 2017 to February 2019 were retrospectively analyzed.Among them,40 patients receiving emergency PCI were iselected as the control group,and 40 patients receiving emergency PCI combined with rh-BNP were selected as the observation group.Cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD)]and related indexes of ventricular collagen remodeling[procollagen type III(PCⅢ),carboxyl terminal peptide of type I procollagen(PⅠCP),matrix metalloproteinase inhibitor(TIMP-1)]were compared between the two groups before and after treatment.Results After treatment,LVEF increased and LVEDD,LVESD decreased in the two groups,and the LVEF and LVEDD,LVESD in the observation group were higher than those in the control group,and the difference was significant(P<0.05).After treatment,the levels of PCⅢand PⅠCP in the two groups were decreased,and the level of TIMP-1 was increased,and the levels of PCⅢand PⅠCP in the observation group were lower than those in the control group,TIMP-1 level was higher than that of control group,and the difference was significant(P<0.05).Conclusion Emergency PCI combined with rh-BNP can improve ventricular collagen remodeling and cardiac function in patients with acute anterior myocardial infarction.