新型广谱杀虫药沙罗拉纳在国外伴侣动物体外寄生虫防治中的应用

Application of New Type of Sarolaner in Ectoparasite Control in Companion Animals in Other Countries

沙罗拉纳(sarolaner)属异恶唑啉类化合物,是一种新型广谱杀虫药。沙罗拉纳已被证实通过特异性阻断昆虫γ-氨基丁酸受体和谷氨酸门控氯离子通道而显示出抗寄生虫活性。本文综述了近年来沙罗拉纳在国外伴侣动物体外寄生虫防治中的开发及临床应用情况,旨在为该药的深入研究和国内开发应用提供参考。近年来,该药主要用于犬猫等伴侣动物体外寄生虫的临床预防和治疗,对蜱类、蚤类、螨类等体外寄生虫有高效的杀灭作用。与其他杀虫药相比,该药在分子结构、作用位点和选择性等方面有显著差异,具有杀虫活性强、治疗剂量低、安全性高等优点。此外,该药通过与多种药物联合应用,可提高治疗效果,扩大治疗范围。就国外研究来看,沙罗拉纳是一种安全广谱的高效杀虫剂,拥有广阔的应用前景。

Sarolaner,a kind of isoxazoline compounds,is a new broad-spectrum insecticide,which could show antiparasitic activity through specifically blocking insectγ-aminobutyric acid(GABA)receptor and glutamategated chloride channel.In the paper,the development and clinical application of Sarolaner in prevention and control of ectoparasites in companion animals in other countries were summarized to provide references for further study,development and application in China.In recent years,the drug had been mainly used for clinical prevention and treatment of ectoparasites in companion animals including dogs and cats,which was highly effective for eradicating ectoparasites such as ticks,fleas and mites.The drug,with the advantages of strong insecticidal activity,low therapeutic dose and high safety,was greatly different from other insecticides in molecular structure,action site and selectivity,etc.In addition,the coverage could be expanded with high effectiveness by combined application of the drug and others.As it was studied in other countries,Sarolaner was a safe,broad-spectrum and highly effective insecticide with promising prospects.