母乳喂养与代谢综合征的关系

Relationship between breast feeding and metabolic syndrome

目的分析母乳喂养与代谢综合征(MS)的关系。方法采用整群抽样、横断面调查方法,回顾性分析REACTION研究所建立的数据库中6250例女性的相关资料,根据母乳喂养情况分为母乳喂养组(n=5786)与非母乳喂养组(n=464),母乳喂养组又进一步分为≤6个月组(n=243)、>6~12个月组(n=4612)、>12~<18个月组(n=691)和≥18个月组(n=240)。分析母乳喂养与MS发生风险的相关性。结果对潜在的混杂因素进行调整,包括年龄、MS既往史、谷氨酸-丙酮酸转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、怀孕次数、流产次数、存活胎儿个数、胎儿性别、妊娠期高血压、妊娠期糖尿病等,与非母乳喂养女性相比,母乳喂养女性患MS的风险降低(OR=0.69,95%CI为0.59~0.98)。与母乳喂养时间≤6个月的女性相比,母乳喂养时间>6~12个月(OR=0.81,95%CI为0.76~1.09)、>12~<18个月(OR=0.75,95%CI为0.68~1.00)和≥18个月(OR=0.78,95%CI为0.65~0.97)的女性患MS的风险均降低。结论母乳喂养在降低产妇产后罹患MS风险中起保护性作用,母乳喂养时间1.0~1.5年即可最大程度地降低发生MS的风险。

Objective To analyze the relationship between breast feeding and metabolic syndrome(MS).Methods Cluster sampling and cross-sectional survey were adopted to retrospectively analyze the data of 6250 women in the database of REACTION institute.According to the breast feeding situation,all the subjects were divided into breast feeding group(n=5786)and non breast feeding group(n=464),and the breast feeding group was further divided into≤6 months group(n=243),>6 to 12 months group(n=4612),>12 to<18 months group(n=691)and≥18 months group(n=240).Correlation between breast feeding and the risk of MS was analyzed.Results After adjusting potential confounding factors such as age,previous history of MS,alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyl transpeptidase(GGT),number of pregnancies,number of abortions,number of surviving fetuses,fetal gender,gestational hypertension and gestational diabetes mellitus,women with breast feeding had a lower risk of MS than those without breast feeding(OR=0.69,95%CI was 0.59 to 0.98).Compared to women with breast feeding less than 6 months,women with breast feeding of>6 to 12 months(OR=0.81,95%CI was 0.76 to 1.09),>12 to<18 months(OR=0.75,95%CI was 0.68 to 1.00)and≥18 months(OR=0.78,95%CI was 0.65 to 0.97)had a lower risk of MS.Conclusion Breast feeding plays a protective role in reducing the risk of postpartum MS,and breast feeding for one year to one year and a half can reduce the risk of MS to the greatest extent.