高通量测序技术在白血病临床应用中的研究进展

Research Advances of High-throughput Sequencing Technology in Clinical Application of Leukemia

高通量测序技术的迅速发展不仅为功能基因组学的研究提供了高效的平台,还在临床肿瘤、精准医学领域呈现出巨大的应用价值。高通量测序技术以通量高、成本低、精确度高、信息量丰富等特点被广泛应用于白血病的临床研究,在揭示肿瘤的异质性、追踪细胞谱系、探索肿瘤克隆演变的复杂机制研究中发挥着重要作用,且在白血病的预后分层、辅助诊断、靶向药物选择等方面显示出较大优势,可以筛选疾病诊断和预后的分子标志物,在一些罕见白血病的治疗中也极具潜力。高通量测序技术可为白血病的临床研究提供强有力的支持,推动白血病实现精准化医疗的进程。

The rapid development of high-throughput sequencing technology not only provides an efficient platform for functional genomics research,but also presents great applicative value in the field of clinical oncology and precision medicine.High-throughput sequencing technology is widely used in clinical research of leukemia due to its high throughput,lower-cost,higher-accuracy and abundant information.It plays an important role in revealing the heterogeneity of tumors,tracking cell lineages and exploring complex mechanism of the evolution of tumor clones,while it also shows great advantages in the prognostic stratification of leukemia,auxiliary diagnosis,targeted drug selection,etc.It can screen molecular markers for the disease diagnosis and prognosis,showing great potential in the treatment of some rare leukemias.High-throughput sequencing technology provides strong support for the clinical research of leukemia,and promotes the process of precise medical treatment for leukemia.